ABSTRACT
Several large scale clinical trials have demonstrated that angiotensin converting enzyme inhibitors offer cardiovascular and renal protection independent of their effects on systolic BP. Trandolapril is a new angiotensin converting enzyme inhibitor approved for the treatment of hypertension. The potential advantages of this drug are long duration of action and better tolerability. The objective of the study was to compare the efficacy and tolerability of trandolapril with that of enalapril in mild to moderate hypertension in Indian population. In this double blind, multicentric, parallel comparative clinical study, 120 patients with mild to moderate hypertension were randomly assigned to receive trandolapril 2 mg or enalapril 5 mg once daily for 8 weeks. The attainment of sitting diastolic blood pressure <90 mmHg at the end of 8th week was considered as primary outcome measure and attainment of diastolic blood pressure <90 mmHg or reduction of at least 10 mmHg diastolic blood pressure compared to baseline at any visit was considered as secondary outcome measures. 98.4% patients treated with trandolapril and 92.6% patients treated with enalapril fulfilled the primary outcome measure. 54, 72 and 62% patients on trandolapril and 52, 61 & 64% patients on enalapril fulfilled secondary outcome measure at the end of 2nd, 4th and 8th week respectively. Also trandolapril was better tolerated than enalapril with no significant abnormality in lab parameters.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/adverse effects , Antihypertensive Agents/adverse effects , Blood Pressure/drug effects , Double-Blind Method , Enalapril/adverse effects , Heart Rate/drug effects , Humans , Hypertension/drug therapy , India , Indoles/adverse effectsABSTRACT
Building related illnesses are a common problem in developed countries and are expected to increase rapidly in urban India. Although objective physical abnormalities are not generally found except in a few specific diseases like Legionnaires' disease, the symptoms can be uncomfortable and even disabling. In this review we initially introduce the concept of indoor air pollution and building related illnesses. Subsequently we review the sources of and exposure to the pollutants along with their health effects and the approach to a patient of suspected building related illness. We conclude by discussing the measures for the control of indoor air pollution.